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Recent research has found out that a gene variant may predict naltrexone treatment success for alcoholism. About 50% of patients of Asian descent use a particular mutation that creates them more likely to benefit from naltrexone, in contrast to about 20% of Caucasians and less than 5% of African Americans, said lead study author Lara Ray, an assistant professor of psychology and director in the UCLA Addictions Laboratory. The findings are presently available online ( inside journal Neuropsychopharmacology and you will be published in an upcoming print edition from the journal. Using two separate drugs to shed weight can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you need to err along the side of caution and allow FDA do its job and demand some study be done so the public knows the side effects and hazards of the medications before we bring them. Keep in mind that drug companies will be in business to generate income and that they would say anything to keep people on their own medications. Researchers found out that participants using this drug for a year, lost weight within one month and have kept the extra weight off throughout the 56 weeks from the study. Contrave is often a combination with the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs which can be made up of many active ingredient, which can make them more efficient and safer. Combo-pilling will be the newest fad or even better the newest in the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is now popular could be the fact that as of right now there aren't any long term prescription slimming capsules that have been approved by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be licensed by the FDA. Seizures certainly are a side effect with Contrave and must not be taken in people with seizure disorders. The drug also can raise blood pressure and pulse rate, and must not be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must not be used in patients with uncontrolled high blood pressure levels, and also by a person with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients towards the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking. "This could be the first drug I'm aware of that targets both the appetite and reward centres inside brain," he explained.