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Using two separate drugs to lose weight can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the people that go through it one should err on the side of caution and allow the FDA do its job and demand some investigation be done so your public is aware of the side effects and perils associated with the medications before we take them. Keep in mind that drug companies will be in business to generate income and that they would say anything to keep people on their medications. Researchers discovered that participants using this drug for any year, lost excess weight within four weeks and have kept the load off throughout the 56 weeks from the study. Contrave is a combination from the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs that are made up of multiple active ingredient, which may make them more efficient and safer. Combo-pilling is the newest fad or better yet the newest into the future under scrutiny and therefore it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills has become popular will be the fact that by right now there are not any long term prescription slimming capsules that have been authorized by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be approved by the FDA. Seizures certainly are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug also can raise blood pressure and heartbeat, and must not be used in individuals with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure and heartbeat and must stop used in patients with uncontrolled high blood pressure, as well as by a person with heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients on the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking. 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