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Contrave is a combination of the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs which might be made up of multiple active ingredient, which can make them more effective and safer. Combo-pilling will be the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills has become popular is the fact that by right now there aren't any long term prescription diet pills that have been authorized by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be authorized by the FDA. Seizures certainly are a side effect with Contrave and must not be taken in people with seizure disorders. 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