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Combo-pilling is the newest fad or in addition to this the newest in the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular could be the fact that as of right now there are not any long term prescription slimming capsules that have been licensed by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be licensed by the FDA. Seizures are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug may also raise blood pressure levels and heartbeat, and mustn't be used in people who have a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure levels and heart rate and must stop used in patients with uncontrolled high blood pressure level, along with by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients using a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients for the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. 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