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Combo-pilling is the newest fad or also the newest into the future under scrutiny and therefore it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular will be the fact that as of right now there aren't long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be licensed by the FDA. Seizures can be a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug could also raise hypertension and heart rate, and really should not be used in individuals with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure and heartbeat and must not used in patients with uncontrolled high blood pressure level, as well as by you are not heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients using a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients for the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking. Approving a drug using this type of many potentially lethal unwanted effects is inconsistent with the mission statement in the FDA. The power in the drug manufacturing lobby is blatantly evident within the approval of countless drugs requiring 'post-marketing' studies that are clearly significant to overall drug safety inside US.